Director, Feasibility

The Director, Feasibility Center of Excellence (CoE) will be responsible for leading and managing feasibility strategy and execution across multiple clinical development programs. Reporting to the Sr. Director of the Feasibility Center of Excellence (CoE), this role plays a key part in driving data-informed decisions for protocol optimization, country/site selection, and patient recruitment forecasting. The Director will lead and oversee the development of feasibility plans, and ensure alignment with clinical, regulatory, and operational goals. This leader will work cross-functionally with Clinical Operations, Clinical Development, Study Start-Up, Data Science, and external vendors to deliver accurate and actionable feasibility insights that support study success.

• Serve as the primary feasibility contact for global studies, supporting timelines, site selection, enrollment projections, and risk mitigation strategies.
• Deliver high-quality feasibility outputs including data analytics, competitive intelligence, and country-specific insights.
• Provide subject matter expertise to internal stakeholders and governance forums; escalate feasibility-related risks with actionable recommendations.
• Lead process improvements and feasibility standards across the organization, contributing to the evolution of the Feasibility CoE vision and strategy.
• Drive KPI development, performance tracking, and business reporting aligned with operational goals.
• Mentor and support junior team members; contribute to a culture of innovation and continuous improvement.
• Champion a patient- and site-centric mindset to ensure inclusive and efficient clinical trial execution.

• Lead the operational delivery of feasibility assessments across a portfolio of clinical trials, from early planning through site selection.
• Ensure timely and high-quality feasibility deliverables that inform protocol design, geographic strategy, protocol optimization, and enrollment forecasting.
• provide expert input on protocol feasibility, complexity of scoring, site burden, and patient eligibility during the study planning phase.
• Collaborate with the Sr. Director to set clear goals, support resource planning, team structure, and functional excellence initiatives.
• Help establish and refine SOPs, work instructions, and best practices for the feasibility function.
• Monitor key performance indicators (KPIs) for feasibility and enrollment predictability across studies.
• Drive quality and consistency in feasibility deliverables across therapeutic areas and regions.

• Partner closely with Clinical Operations, Clinical Science, Commercial, Study Start-Up, etc. to integrate feasibility insights into study planning.
• Coordinate with external partners (CROs, data vendors, consultants) for feasibility data sourcing and modeling support.
• Present feasibility findings and recommendations to cross-functional stakeholders and governance bodies.

• Leverage a wide range of internal and external data sources to inform feasibility assessments, including RWD/RWE, site metrics, epidemiology, and historic trial performance.
• Promote the use of digital tools, predictive analytics, and AI-driven platforms in feasibility forecasting and modeling.
• Contribute to the continuous improvement of feasibility templates, dashboards, and methodologies.

• Bachelor's Degree in Life Science or related discipline (Master's degree or higher preferred)

• Minimum 10 years of experience in clinical research, feasibility, or clinical operations within a pharmaceutical, biotech, or CRO setting.
• Minimum 3-5 years of feasibility-focused role.
• Demonstrated ability to lead end-to-end feasibility assessments across multiple studies and/or indications.
• Deep knowledge of clinical trial design, patient recruitment challenges, and global study execution.
• Proficiency with feasibility data sources and tools, and data interpretation skills; familiarity with tools like CTMS, Citeline, IQVIA, RWD sources, and feasibility modeling platforms.
• Excellent leadership, communication, and interpersonal skills.
• Strategic thinker with strong project management and organizational abilities.
• Demonstrated ability to influence, collaborate, and lead change across a complex matrixed environment.
• Willingness to travel up to 10-15%, including international as required

U.S. Pay Range

$191,300.00 - $258,700.00

The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity).

Alnylam's robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together.

Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: https://www.alnylam.com/careers

AboutAlnylam

We are the leader in RNAi therapeutics- a revolutionaryapproach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possibleand are just at the beginning of what's possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, wherean authentic, inclusive culture and breakthrough thinkingfuel one another.

At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.