Assistant Professional Researcher - Okada lab

Assistant Professional Researcher - Okada lab

The Okada lab in the Department of Neurological Surgery at UCSF seeks a highly motivated Assistant Professional Researcher to provide scientific leadership in the development and implementation of innovative research programs advancing therapies for malignant brain tumors. The successful candidate will work collaboratively with faculty, trainees, and national and international research partners to accelerate the translation of discoveries in brain tumor immunotherapy into improved patient care.

The primary objective of this position is to advance breakthrough therapeutic strategies for brain tumors through integrated studies of tumor immunology, genetics, epigenetics, and mechanisms of treatment resistance. The incumbent will provide scientific leadership within multidisciplinary, grant-funded research programs, identify actionable therapeutic vulnerabilities, and develop innovative therapeutic approaches. This position serves as a senior scientific collaborator, contributing to strategic planning, project management, experimental design, data interpretation, and research program development across multiple concurrent initiatives.

The Professional Researcher will work closely with faculty and staff across UCSF to foster interdisciplinary collaborations, while playing a leading role in large national and international research consortia. The incumbent will also mentor graduate students, postdoctoral scholars, and research staff, providing scientific guidance, technical training, and oversight of laboratory and computational research activities.

Essential Responsibilities:

Specific job expectations include, but are not limited to:

1. Provide scientific leadership and project management for funded collaborative research programs focused on brain tumor immunology, metabolism, and immunotherapy.
2. Participate in weekly one-on-one meetings with the PI, weekly laboratory meetings, and project-specific meetings, except when laboratory responsibilities require otherwise.
3. Train and mentor new laboratory members in laboratory safety, cell culture techniques, specimen processing, spectral flow cytometry, bioinformatics, data management, data security, and other laboratory methodologies as needed. Provide ongoing feedback, evaluate trainee progress, and communicate progress to the PI.
4. Promote a culture of scientific rigor, laboratory safety, regulatory compliance, and research integrity, serving as a role model and resource for laboratory personnel.
5. Coordinate multiple collaborative projects simultaneously, ensuring timely completion of milestones, accurate documentation, and effective communication among collaborators.
6. Work flexible hours, including occasional evenings, weekends, or holidays, as needed to accommodate time-sensitive experiments or the processing of clinical specimens.

Required Qualifications:

• MD, PhD, or equivalent doctoral degree.
• Clinical experience or a strong understanding of the clinical management of patients with malignant brain tumors, including neurosurgery, neuro-oncology, and contemporary molecular neuropathology.
• Demonstrated expertise in cancer biology and cancer immunology, including immunotherapeutic approaches.
• Extensive knowledge of genetics and epigenetics, including experimental design, execution, data analysis, interpretation, and scientific reporting.
• Demonstrated ability to independently design, execute, troubleshoot, and analyze experiments using: 1) spectral flow cytometry; 2) real-time cell killing assays; 3) CRISPR/Cas9-based genome editing; 4) PCR/qPCR; and 5) relevant preclinical experimental models.
• Demonstrated ability to independently design, operate, troubleshoot, and analyze high-throughput sequencing studies, including 1) bulk RNA-seq; 2) single-cell RNA-seq (including GEX/VDJ); 3) single-cell ATAC-seq; 4) single-cell spatial transcriptomics; 5) long-read sequencing technologies.
• Proficiency in computational biology and scientific programming (R and/or Python) within Linux-based high-performance computing environments.
• Experience with version control and collaborative coding platforms (e.g., GitHub).

Preferred Qualifications:

• MD/PhD is preferred.
• Board certification (U.S. or international) preferred.
• Demonstrated success in securing competitive research funding through grants or research awards.
• Strong publication record demonstrating sustained research productivity in the relevant research field.
• At least 5 years of experience supervising, mentoring, and training scientists in an academic research laboratory.

Candidates must meet all required qualifications at the time of application, and application materials must clearly document how these qualifications are met.

See Table 13B for the salary range for this position. A reasonable estimate for this position is $96,700 - $126,400.

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As a University employee, you will be required to comply with all applicable University policies and/or collective bargaining agreements, as may be amended from time to time. Federal, state, or local government directives may impose additional requirements.

The University of California is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected status under state or federal law.

UCSF is committed to welcoming and serving all people, honoring the dignity of every individual without preference or prejudice, in support of its public mission and in alignment with our PRIDE values and Principles of Community.

As a condition of employment, the finalist will be required to disclose if they are subject to any final administrative or judicial decisions within the last seven years determining that they committed any misconduct.

* "Misconduct" means any violation of the policies or laws governing conduct at the applicant's previous place of employment, including, but not limited to, violations of policies or laws prohibiting sexual harassment, sexual assault, or other forms of harassment, or discrimination, as defined by the employer.

* UC Sexual Violence and Sexual Harassment Policy

* UC Anti-Discrimination Policy

* APM - 035: Affirmative Action and Nondiscrimination in Employment